{"id":3816,"date":"2023-01-11T07:44:53","date_gmt":"2023-01-11T05:44:53","guid":{"rendered":"https:\/\/hhac.de\/methods\/"},"modified":"2024-07-29T15:47:32","modified_gmt":"2024-07-29T13:47:32","slug":"methods","status":"publish","type":"page","link":"https:\/\/hhac.de\/en\/services\/methods\/","title":{"rendered":"Methods"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-ki9k60-f8e8eb4faa9aeb864a05c0936e7e51ef\">\n.avia-section.av-ki9k60-f8e8eb4faa9aeb864a05c0936e7e51ef{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-ki9k60-f8e8eb4faa9aeb864a05c0936e7e51ef main_color avia-section-default avia-no-border-styling  avia-builder-el-0  avia-builder-el-no-sibling  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-3816'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-5n3fx4-dd9e1bb2cfc67212332815feb0eafbc8\">\n.flex_column.av-5n3fx4-dd9e1bb2cfc67212332815feb0eafbc8{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-5n3fx4-dd9e1bb2cfc67212332815feb0eafbc8 av_two_third  avia-builder-el-1  el_before_av_one_full  avia-builder-el-first  first flex_column_div av-zero-column-padding '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-23o1bc-445e03b4cfddfe3de1e500d56a86c312\">\n#top .hr.hr-invisible.av-23o1bc-445e03b4cfddfe3de1e500d56a86c312{\nmargin-top:-50px;\nheight:1px;\n}\n<\/style>\n<div  class='hr av-23o1bc-445e03b4cfddfe3de1e500d56a86c312 hr-invisible  avia-builder-el-2  el_before_av_heading  avia-builder-el-first '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94\">\n#top .av-special-heading.av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94{\npadding-bottom:30px;\nfont-size:50px;\n}\nbody .av-special-heading.av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94 .av-special-heading-tag{\nfont-size:50px;\n}\n.av-special-heading.av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n<\/style>\n<div  class='av-special-heading av-lcyv9zg4-9c49be5ad958fd84a76d4db1be4f6f94 av-special-heading-h1 blockquote modern-quote  avia-builder-el-3  el_after_av_hr  el_before_av_textblock  av-inherit-size'><h1 class='av-special-heading-tag'  itemprop=\"headline\"  >List of methods <\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-lcyva5sn-98d5adf3acafa97a692296aa6fef9146'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>The listing includes the standard methods available at HHAC &#8211; in addition, we develop specific methods for release or stability testing on customer order.<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3ofxk8-1d3d6fb69c57f4bf80ad4737dbf78b95\">\n#top .hr.hr-invisible.av-3ofxk8-1d3d6fb69c57f4bf80ad4737dbf78b95{\nmargin-top:-50px;\nheight:1px;\n}\n<\/style>\n<div  class='hr av-3ofxk8-1d3d6fb69c57f4bf80ad4737dbf78b95 hr-invisible  avia-builder-el-5  el_after_av_textblock  avia-builder-el-last  av-small-hide av-mini-hide'><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p><\/div><div class='flex_column av-9g5fdk-e9182bc4c0fa7eef1e6a983243565680 av_one_full  avia-builder-el-6  el_after_av_two_third  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-lcrdqaad-688f2f1d9e52e2501ed6cbc2ac3f89fd'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Performance of climatic storage and stability tests of active pharmaceutical ingredients, excipients and finished products<br \/>\n<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lcrcxoz3-1907dbce586ffd48741df2b8dbce97ca'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">ICH Q1A (R)<br \/>\nEMA<br \/>\n(CPMP\/ICH\/2736\/99)<br \/>\n(CPMP\/QWP\/122\/02, rev 1)<\/td>\n<td style=\"width: 20%; height: 19px;\">Stability testing according to ICH<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">ICH Q1B EMA (CPMP\/ICH\/279\/95)<\/td>\n<td style=\"width: 20%; height: 19px;\">Photostability tests according to ICH<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">EMA (CPMP\/QWP\/2934\/99)<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing of the in-use stability of finished medicinal products<br \/>\n(in-use stability)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-xrz6w-af127375bffb5a876ccec610b32c5a1f\">\n.flex_column.av-xrz6w-af127375bffb5a876ccec610b32c5a1f{\nwidth:100%;\n}\n<\/style>\n<div class='flex_column av-xrz6w-af127375bffb5a876ccec610b32c5a1f av_one_full  avia-builder-el-9  el_after_av_one_full  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-1wfmbc-89391e8f3bbe5881b2dd188f42e178ca'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Testing of light-sensitive active pharmaceutical ingredients and finished drug products under light protection<br \/>\n<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-3lrwrs-7411c2f7a478948794eb6b58a2033c95'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr>\n<th style=\"width: 50%;\">Test methods<\/th>\n<th style=\"width: 50%;\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"width: 50%;\">HHAC AOG037<\/td>\n<td style=\"width: 50%;\">Working under light protection<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div><div class='flex_column av-lsbniw-75e8caf120683ce4a082d5026fa0e4c9 av_one_full  avia-builder-el-12  el_after_av_one_full  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-lcrd0g2r-cf3d81e09733a6aa1172d73d87c82f99'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>High performance liquid chromatography (HPLC) test method<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lcrdcq3p-13a08352e7cf923ec522603f8fbe0bee'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.29<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing the identity of active pharmaceutical ingredients and excipients by HPLC<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.29<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of the content of active pharmaceutical ingredients and excipients by HPLC<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.29<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing for purity\/related substances of active pharmaceutical ingredients and excipients by HPLC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div><div class='flex_column av-lgceu0-9e91ae1928fcb552a63da9c6c3b19a9a av_one_full  avia-builder-el-15  el_after_av_one_full  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-lcrdesar-1ba32aabb58cd4bc315b4722b3f690cf'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Test method Gas chromatography (GC)<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lcrdgcd8-22ec821cabf8baed2f42b690b61d7cbe'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.28<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing for identity of active pharmaceutical ingredients and excipients by GC<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.28<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of content of active pharmaceutical ingredients and excipients by GC<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.28<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing for purity\/related substances of active pharmaceutical ingredients and excipients by GC<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.4.24<\/td>\n<td style=\"width: 20%; height: 19px;\">Identification and control of residual solvents in active pharmaceutical ingredients, excipients and drugs by headspace GC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div><div class='flex_column av-qx2aw-acb843d966c9412b46fd10577a63e8b0 av_one_full  avia-builder-el-18  el_after_av_one_full  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-hs9tpk-7dc57a9f853ad5a6fa9b22f3af7df18e'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Test method Thin layer chromatography (TLC)<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-f4ne8o-02def960899c552aded3e9b794313149'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.27<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing the identity of active pharmaceutical ingredients and excipients by TLC<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.27<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of content of active pharmaceutical ingredients and excipients by TLC<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.27<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing for purity\/related substances of active pharmaceutical ingredients and excipients by means of TLC<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div><div class='flex_column av-cued0o-eced26202c74d0e43d6dbd114689acb1 av_one_full  avia-builder-el-21  el_after_av_one_full  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-lcrdguu4-1afbabd0efa4197ddcc964660a30c8f1'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Test method Spectroscopy<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lcrdhvnw-6fe87aeec40887b5ce50b364d68618d7'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.24<\/td>\n<td style=\"width: 20%; height: 19px;\">Absorption spectrophotometry, infrared<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.25<\/td>\n<td style=\"width: 20%; height: 19px;\">Absorption spectrophotometry, ultraviolet and visible<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.25<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of the content of active pharmaceutical ingredients and excipients by UV-Vis spectroscopy<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div><div class='flex_column av-6g61e0-0f0c76ed21e2e3a00108f51db576ea21 av_one_full  avia-builder-el-24  el_after_av_one_full  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-3zyo48-2ee46acb4aaad758472b234582d74285'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Titrimetric, gravimetric and wet chemical test methods<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-2pi7s8-a4c09d908fd7e88284843918893777ff'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.20<\/td>\n<td style=\"width: 20%; height: 19px;\">Content determination of active pharmaceutical ingredients and excipients by potentiometric titration<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.5.1<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of acid value by acidimetric titration<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.5.5<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of the peroxide value by iodometric titration<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.5.11<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of the content of active pharmaceutical ingredients by complexometric titration<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.5.12<\/td>\n<td style=\"width: 20%; height: 19px;\">Semi-micro determination of water by the Karl Fischer method<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.5.32<\/td>\n<td style=\"width: 20%; height: 19px;\">Micro determination of water &#8211; Coulometric titration<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.32<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of loss on drying<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">HHAC ANC034<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of loss on drying by infrared dryer<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.38<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of conductivity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div><div class='flex_column av-61ik6w-ff76090d675ffafc0d1aa1370f950666 av_one_full  avia-builder-el-27  el_after_av_one_full  el_before_av_one_full  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-4rh3zc-debc59f1c4a3198481d3b7e9101b59ff'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Testing of the release of the active ingredient<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-2vp4h4-c9f99bce2f7d57fbbbb5d27f00b1717a'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.9.3<\/td>\n<td style=\"width: 20%; height: 19px;\">Dissolution test for solid dosage forms<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><\/p><\/div><div class='flex_column av-5tgkdk-c0a72718043d1cf4c2e58582ef8f0f81 av_one_full  avia-builder-el-30  el_after_av_one_full  el_before_av_one_half  first flex_column_div column-top-margin'     ><p><section  class='av_textblock_section av-4ecadk-3248d623f2f4d845ccc9212871c7a12a'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Testing of composition according to pharmacopoeial methods<\/strong><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-38dfy0-41b714cb32cff7d8caca95cf2bc22cc9'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table class=\" alignleft\" style=\"border-collapse: collapse; width: 100%;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Test methods<\/th>\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Testing<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.1<\/td>\n<td style=\"width: 20%; height: 19px;\">Testing of clarity and degree of opalescence of liquids<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.2<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of degree of coloration of liquids<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.3<\/td>\n<td style=\"width: 20%; height: 19px;\">pH value &#8211; potentiometric determination<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.5<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of relative density<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.6<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of refractive index<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.10<\/td>\n<td style=\"width: 20%; height: 19px;\">Viscosity &#8211; Rotating viscometer method<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.2.35<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of osmolality<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.9.1<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of disintegration of tablets and capsules<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. Monograph 0478<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of disintegration of effervescent tablets<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.9.7<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of the friability of uncoated tablets<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.9.8<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of resistance to crushing of tablets<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.9.20<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of particulate contamination (visible particles)<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Ph. Eur. 2.9.40<\/td>\n<td style=\"width: 20%; height: 19px;\">Determination of uniformity of single-dose dosage forms<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">DAB V.6.9.N1<\/td>\n<td style=\"width: 20%; height: 19px;\">Boiling temperature<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3qpldk-19ffc1097a8e52b3913b3023968ecc67\">\n#top .hr.hr-invisible.av-3qpldk-19ffc1097a8e52b3913b3023968ecc67{\nheight:20px;\n}\n<\/style>\n<div  class='hr av-3qpldk-19ffc1097a8e52b3913b3023968ecc67 hr-invisible  avia-builder-el-33  el_after_av_textblock  avia-builder-el-last '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-63t2vc-5c92ae6bd9d34abc61e963712aa82d5b\">\n.flex_column.av-63t2vc-5c92ae6bd9d34abc61e963712aa82d5b{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-63t2vc-5c92ae6bd9d34abc61e963712aa82d5b av_one_half  avia-builder-el-34  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3khttk-625e9c2dd0f756ab434e28f96b53e681\">\n.avia-image-container.av-3khttk-625e9c2dd0f756ab434e28f96b53e681 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-3khttk-625e9c2dd0f756ab434e28f96b53e681 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-3khttk-625e9c2dd0f756ab434e28f96b53e681 av-styling- avia-align-left  avia-builder-el-35  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-3115 avia-img-lazy-loading-not-3115 avia_image ' src=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3.jpg\" alt='' title=''  height=\"1481\" width=\"2000\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3.jpg 2000w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3-300x222.jpg 300w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3-1030x763.jpg 1030w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3-768x569.jpg 768w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3-1536x1137.jpg 1536w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3-1500x1111.jpg 1500w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-hhac-labor-dr-heusler-3-705x522.jpg 705w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/><\/div><\/div><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-5t09yg-4216107a3c55b12354c7d431bad98ac6\">\n.flex_column.av-5t09yg-4216107a3c55b12354c7d431bad98ac6{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-5t09yg-4216107a3c55b12354c7d431bad98ac6 av_one_half  avia-builder-el-36  el_after_av_one_half  el_before_av_one_full  flex_column_div av-zero-column-padding column-top-margin'     ><p><section  class='av_textblock_section av-lcre8qve-12e66ca5a898ed3d69b5642041112e65'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><strong>Sources<\/strong><\/p>\n<p><em>Sources<\/em><br \/>\nPh. Eur: European Pharmacopoeia<br \/>\nICH: International Conference on Harmonisation<br \/>\nEMA: European Medicines Agency<br \/>\nCPMP: Committee for Proprietary Medicinal Products<br \/>\nDAB: German Pharmacopoeia<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-aocx4-d148cbdb18e12b93b89b7b23efd17d6a\">\n#top .hr.hr-invisible.av-aocx4-d148cbdb18e12b93b89b7b23efd17d6a{\nheight:20px;\n}\n<\/style>\n<div  class='hr av-aocx4-d148cbdb18e12b93b89b7b23efd17d6a hr-invisible  avia-builder-el-38  el_after_av_textblock  avia-builder-el-last '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p><\/div><div class='flex_column av-7c15oo-06d3efd370671f23fb503e41edc1fe44 av_one_full  avia-builder-el-39  el_after_av_one_half  el_before_av_one_half  first flex_column_div column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-5t44ug-3b54326e12118fe9f038105c751f2bad\">\n#top .hr.hr-invisible.av-5t44ug-3b54326e12118fe9f038105c751f2bad{\nheight:30px;\n}\n<\/style>\n<div  class='hr av-5t44ug-3b54326e12118fe9f038105c751f2bad hr-invisible  avia-builder-el-40  el_before_hhac_cta_bar  avia-builder-el-first '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<div class=\"hhac-cta-bar\">\n\t<div class=\"hhac-cta-bar__heading\">\n\t\tWe will gladly <span class=\"md-block\">advise you<\/span>\t<\/div>\n\t<div class=\"hhac-cta-bar__email\">\n\t\t<div class=\"hhac-cta-bar__label\">Email<\/div>\n\t\t<a href=\"mailto:hhac@hhac.de\" class=\"hhac-cta-bar__link\">hhac@hhac.de<\/a>\n\t<\/div>\n\t<div class=\"hhac-cta-bar__phone\">\n\t\t<div class=\"hhac-cta-bar__label\">Phone<\/div>\n\t\t<a href=\"tel:+497249913020\" class=\"hhac-cta-bar__link\">+49 7249 91302-0<\/a>\n\t<\/div>\n\t<div class=\"hhac-cta-bar__action\">\n\t\t<a href=\"https:\/\/hhac.de\/en\/contact\/\" class=\"hhac-cta-bar__button\">Contact<\/a>\n\t<\/div>\n<\/div>\n<br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2rr8g8-cd65f3758410613c0cdca3cca462b603\">\n#top .hr.hr-invisible.av-2rr8g8-cd65f3758410613c0cdca3cca462b603{\nheight:30px;\n}\n<\/style>\n<div  class='hr av-2rr8g8-cd65f3758410613c0cdca3cca462b603 hr-invisible  avia-builder-el-42  el_after_hhac_cta_bar  avia-builder-el-last '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-g55p20-5bd918d9c921d6c0c98c433800f1c37b\">\n.flex_column.av-g55p20-5bd918d9c921d6c0c98c433800f1c37b{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-g55p20-5bd918d9c921d6c0c98c433800f1c37b av_one_half  avia-builder-el-43  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lcrcprdc-4133547b04ac19080c3ae5b0bdf351c9\">\n#top .av_textblock_section.av-lcrcprdc-4133547b04ac19080c3ae5b0bdf351c9 .avia_textblock{\ncolor:#b8b9bb;\n}\n<\/style>\n<section  class='av_textblock_section av-lcrcprdc-4133547b04ac19080c3ae5b0bdf351c9'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><h3>LIST OF<\/h3>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-ee5tjc-18b171aab174fd1374991f6eee2f4d16\">\n#top .hr.hr-invisible.av-ee5tjc-18b171aab174fd1374991f6eee2f4d16{\nmargin-top:-50px;\nheight:1px;\n}\n<\/style>\n<div  class='hr av-ee5tjc-18b171aab174fd1374991f6eee2f4d16 hr-invisible  avia-builder-el-45  el_after_av_textblock  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb\">\n#top .av-special-heading.av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb{\npadding-bottom:30px;\nfont-size:50px;\n}\nbody .av-special-heading.av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb .av-special-heading-tag{\nfont-size:50px;\n}\n.av-special-heading.av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb .av-special-heading-tag{\nfont-size:30px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb .av-special-heading-tag{\nfont-size:30px;\n}\n}\n<\/style>\n<div  class='av-special-heading av-lcrcpcmq-8021a832cccfc0f305e34d9060dae5eb av-special-heading-h2 blockquote modern-quote  avia-builder-el-46  el_after_av_hr  el_before_av_textblock  av-inherit-size'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >Methods<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-lcrcpzr1-421c2c320360893f929eb759b841cdbd'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>The above listing of our methods summarizes the standard methods available at HHAC. In addition, we develop specific methods for release or stability testing for our customers.<\/p>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-je2su0-3707688c6fbb64c0cbc2561ea0e1eb42\">\n.flex_column.av-je2su0-3707688c6fbb64c0cbc2561ea0e1eb42{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-je2su0-3707688c6fbb64c0cbc2561ea0e1eb42 av_one_half  avia-builder-el-48  el_after_av_one_half  avia-builder-el-last  flex_column_div av-zero-column-padding column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-67e60-6cfad865dad720b6d29ec8f5779b7a1c\">\n.avia-image-container.av-67e60-6cfad865dad720b6d29ec8f5779b7a1c img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-67e60-6cfad865dad720b6d29ec8f5779b7a1c .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-67e60-6cfad865dad720b6d29ec8f5779b7a1c av-styling- avia-align-left  avia-builder-el-49  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-3113 avia-img-lazy-loading-not-3113 avia_image ' src=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg.jpg\" alt='' title=''  height=\"1330\" width=\"2000\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg.jpg 2000w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg-300x200.jpg 300w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg-1030x685.jpg 1030w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg-768x511.jpg 768w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg-1536x1021.jpg 1536w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg-1500x998.jpg 1500w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methoden-02-hhac-labor-dr-heusler.jpg-705x469.jpg 705w\" sizes=\"(max-width: 2000px) 100vw, 2000px\" \/><\/div><\/div><\/div><\/div><\/div><\/div><\/main><!-- close content main element --><\/div><\/div><div id='after_section_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-3816'><div class='entry-content-wrapper clearfix'>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":13,"featured_media":0,"parent":3781,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3816","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages\/3816","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/comments?post=3816"}],"version-history":[{"count":0,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages\/3816\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages\/3781"}],"wp:attachment":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/media?parent=3816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}