{"id":3797,"date":"2022-09-13T13:42:08","date_gmt":"2022-09-13T11:42:08","guid":{"rendered":"https:\/\/hhac.de\/services\/method-development\/"},"modified":"2024-07-29T15:59:49","modified_gmt":"2024-07-29T13:59:49","slug":"method-development","status":"publish","type":"page","link":"https:\/\/hhac.de\/en\/services\/method-development\/","title":{"rendered":"Method development"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l6w4p19d-20-039a628e1d5b432b125befa813b127d0\">\n.avia-section.av-l6w4p19d-20-039a628e1d5b432b125befa813b127d0{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-l6w4p19d-20-039a628e1d5b432b125befa813b127d0 main_color avia-section-default avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><main  role=\"main\" 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img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-3651yg-ff0074285142e1416b5bc3c8d356f6b9 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-3651yg-ff0074285142e1416b5bc3c8d356f6b9 av-styling- avia-align-center  avia-builder-el-2  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-3078 avia-img-lazy-loading-not-3078 avia_image ' src=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenentwicklung-hhac-labor-dr-heusler-scaled.jpg\" alt='' title=''  height=\"2560\" width=\"1790\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenentwicklung-hhac-labor-dr-heusler-scaled.jpg 1790w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenentwicklung-hhac-labor-dr-heusler-210x300.jpg 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0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-asai7-19-97a8c553c7cf176a7943f42e1e611fde av_one_half  avia-builder-el-3  el_after_av_one_half  el_before_av_one_full  flex_column_div av-zero-column-padding '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-7tej6n-5498066091ce0c25d07f6be4b3d77727\">\n#top .av_textblock_section.av-7tej6n-5498066091ce0c25d07f6be4b3d77727 .avia_textblock{\ncolor:#b8b9bb;\n}\n<\/style>\n<section  class='av_textblock_section av-7tej6n-5498066091ce0c25d07f6be4b3d77727'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><h3>BRIEFLY EXPLAINED<\/h3>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l6xaspxr-e4cb2a5b62421c0b114b9a8722df0188\">\n#top .hr.hr-invisible.av-l6xaspxr-e4cb2a5b62421c0b114b9a8722df0188{\nmargin-top:-50px;\nheight:1px;\n}\n<\/style>\n<div  class='hr av-l6xaspxr-e4cb2a5b62421c0b114b9a8722df0188 hr-invisible  avia-builder-el-5  el_after_av_textblock  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-35peoo-6ebd86e19589df70dc1db9ef74e186c0\">\n#top .av-special-heading.av-35peoo-6ebd86e19589df70dc1db9ef74e186c0{\npadding-bottom:30px;\nfont-size:50px;\n}\nbody .av-special-heading.av-35peoo-6ebd86e19589df70dc1db9ef74e186c0 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-35peoo-6ebd86e19589df70dc1db9ef74e186c0 .av-special-heading-tag{\nfont-size:50px;\n}\n.av-special-heading.av-35peoo-6ebd86e19589df70dc1db9ef74e186c0 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-35peoo-6ebd86e19589df70dc1db9ef74e186c0 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-35peoo-6ebd86e19589df70dc1db9ef74e186c0 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n<\/style>\n<div  class='av-special-heading av-35peoo-6ebd86e19589df70dc1db9ef74e186c0 av-special-heading-h1 blockquote modern-quote  avia-builder-el-6  el_after_av_hr  el_before_av_textblock  av-inherit-size'><h1 class='av-special-heading-tag'  itemprop=\"headline\"  >Method development<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-7tej6n-17-85877aa53cd057e9086b428d1e35aa9c'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Regardless of whether release testing or stability testing, regardless of whether synthetic or herbal drugs or raw materials have to be analyzed:<\/p>\n<\/div><\/section><br \/>\n\n\t\t\t\t\t<div class=\"hhac-highlight-block\">\n\t\t\t\t<br \/>\nSince 1992, we have been developing customized methods for robust, reliable routine operation and have already established methods for testing quality-relevant parameters for more than 400 different active pharmaceutical ingredients.<br \/>\n\t\t\t<\/div>\n\t\t\n\t\t<br \/>\n\n\t\t\t\t\t<div class=\"hhac-highlight-block\">\n\t\t\t\t<br \/>\nAfter the (de novo) development or optimization of a method, we validate it &#8220;state-of-the-art&#8221; according to the validation plan, in particular according to ICH guidelines.<br \/>\n\t\t\t<\/div>\n\t\t\n\t\t<br \/>\n\n\t\t\t\t\t<div class=\"hhac-highlight-block\">\n\t\t\t\t<br \/>\nOf course, customer-specific requirements (SOPs) are also taken into account.<br \/>\n\t\t\t<\/div>\n\t\t\n\t\t<br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" 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ease-in-out;\ntransition:all 0.4s ease-in-out;\n}\n<\/style>\n<a href='#kontakt'  class='avia-button av-l805grfq-ebf8064927eaef635b78ed133fe76137 avia-icon_select-no avia-size-x-large avia-position-left'  ><span class='avia_iconbox_title' >Request now<\/span><\/a><\/div><\/p><\/div><div class='flex_column av-737i14-a2fad70e16db6faab534c9739ad244c5 av_one_full  avia-builder-el-13  el_after_av_one_half  el_before_av_one_half  first flex_column_div column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-6fz608-699a1e36a6a5b500e741a6c72b210ceb\">\n#top .hr.hr-invisible.av-6fz608-699a1e36a6a5b500e741a6c72b210ceb{\nheight:30px;\n}\n<\/style>\n<div  class='hr av-6fz608-699a1e36a6a5b500e741a6c72b210ceb hr-invisible  avia-builder-el-14  el_before_hhac_cta_bar  avia-builder-el-first '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<div class=\"hhac-cta-bar\">\n\t<div class=\"hhac-cta-bar__heading\">\n\t\tWe will gladly <span class=\"md-block\">advise you<\/span>\t<\/div>\n\t<div class=\"hhac-cta-bar__email\">\n\t\t<div class=\"hhac-cta-bar__label\">Email<\/div>\n\t\t<a href=\"mailto:hhac@hhac.de\" class=\"hhac-cta-bar__link\">hhac@hhac.de<\/a>\n\t<\/div>\n\t<div class=\"hhac-cta-bar__phone\">\n\t\t<div class=\"hhac-cta-bar__label\">Phone<\/div>\n\t\t<a href=\"tel:+497249913020\" class=\"hhac-cta-bar__link\">+49 7249 91302-0<\/a>\n\t<\/div>\n\t<div class=\"hhac-cta-bar__action\">\n\t\t<a href=\"https:\/\/hhac.de\/en\/contact\/\" class=\"hhac-cta-bar__button\">Contact<\/a>\n\t<\/div>\n<\/div>\n<br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-30gsk8-a3ba9fada421655b3fdf16972740d526\">\n#top .hr.hr-invisible.av-30gsk8-a3ba9fada421655b3fdf16972740d526{\nheight:30px;\n}\n<\/style>\n<div  class='hr av-30gsk8-a3ba9fada421655b3fdf16972740d526 hr-invisible  avia-builder-el-16  el_after_hhac_cta_bar  avia-builder-el-last '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-asai7-18-9ed5bdd27f68c2d8037eba380357ebcb\">\n.flex_column.av-asai7-18-9ed5bdd27f68c2d8037eba380357ebcb{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-asai7-18-9ed5bdd27f68c2d8037eba380357ebcb av_one_half  avia-builder-el-17  el_after_av_one_full  el_before_av_one_half  first av-break-at-tablet flex_column_div av-zero-column-padding column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-7tej6n-15-5283d7782ad2c8c11c6e76dac1815620\">\n#top .av_textblock_section.av-7tej6n-15-5283d7782ad2c8c11c6e76dac1815620 .avia_textblock{\ncolor:#b8b9bb;\n}\n<\/style>\n<section  class='av_textblock_section av-7tej6n-15-5283d7782ad2c8c11c6e76dac1815620'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><h3>BRIEFLY EXPLAINED<\/h3>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l6xaspxr-11-70e7113fd760afd6d86ee89a3bcf36d3\">\n#top .hr.hr-invisible.av-l6xaspxr-11-70e7113fd760afd6d86ee89a3bcf36d3{\nmargin-top:-50px;\nheight:1px;\n}\n<\/style>\n<div  class='hr av-l6xaspxr-11-70e7113fd760afd6d86ee89a3bcf36d3 hr-invisible  avia-builder-el-19  el_after_av_textblock  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059\">\n#top .av-special-heading.av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059{\npadding-bottom:30px;\nfont-size:50px;\n}\nbody .av-special-heading.av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059 .av-special-heading-tag{\nfont-size:50px;\n}\n.av-special-heading.av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n<\/style>\n<div  class='av-special-heading av-atjbjc-e3d2e29b5cdef9d33d06cc8efcb9a059 av-special-heading-h2 blockquote modern-quote  avia-builder-el-20  el_after_av_hr  el_before_av_textblock  av-inherit-size'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >Method validation<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-7tej6n-9-9963d0154adf9716d7d2589cf4f233da'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>When validating purity, assay and release methods, we define the required scope of validation in close consultation with you. With this specification we check the method specifically for the impact of critical parameters (risk assessment).<\/p>\n<p>If we carry out controlled degradation studies (concerning purity methods), special consideration is given to factors such as light, heat, oxidative, acidic and alkaline stress. Following the risk assessment, we determine the acceptance criteria and record them in the validation plan. Of course, we also carry out validations of established methods according to customer-specific validation plans!<\/p>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l6xaspxr-8-26d768d62e754ab26147786ac855f83b\">\n#top .hr.hr-invisible.av-l6xaspxr-8-26d768d62e754ab26147786ac855f83b{\nheight:20px;\n}\n<\/style>\n<div  class='hr av-l6xaspxr-8-26d768d62e754ab26147786ac855f83b hr-invisible  avia-builder-el-22  el_after_av_textblock  el_before_av_button '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<div  class='avia-button-wrap av-l805grfq-13-3ae846359da91deba07ee038e2c7c5da-wrap avia-button-left  avia-builder-el-23  el_after_av_hr  avia-builder-el-last '>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l805grfq-13-3ae846359da91deba07ee038e2c7c5da\">\n#top #wrap_all 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el_after_av_one_half  avia-builder-el-last  av-break-at-tablet flex_column_div av-zero-column-padding column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l809hfcq-65b1fff05936e4efae70a8872163dca1\">\n.avia-image-container.av-l809hfcq-65b1fff05936e4efae70a8872163dca1 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-l809hfcq-65b1fff05936e4efae70a8872163dca1 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-l809hfcq-65b1fff05936e4efae70a8872163dca1 av-styling- avia-align-center  avia-builder-el-25  avia-builder-el-no-sibling '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" class='wp-image-3076 avia-img-lazy-loading-not-3076 avia_image ' src=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler.jpg\" alt='' title=''  height=\"1777\" width=\"2020\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler.jpg 2020w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler-300x264.jpg 300w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler-1030x906.jpg 1030w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler-768x676.jpg 768w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler-1536x1351.jpg 1536w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler-1500x1320.jpg 1500w, https:\/\/hhac.de\/wp-content\/uploads\/2023\/01\/methodenvalidierung-hhac-labor-dr-heusler-705x620.jpg 705w\" sizes=\"(max-width: 2020px) 100vw, 2020px\" \/><\/div><\/div><\/div><\/div><\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l6w4p19d-12-8e707966ac3b47d3d7af0dea5dc1288a\">\n.avia-section.av-l6w4p19d-12-8e707966ac3b47d3d7af0dea5dc1288a{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-l6w4p19d-12-8e707966ac3b47d3d7af0dea5dc1288a main_color avia-section-default avia-no-border-styling  avia-builder-el-26  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-3797'><div class='entry-content-wrapper clearfix'>\n<div class='flex_column av-1zap9k-3cd5273206d437ad6bcde1cf7d0e7685 av_one_full  avia-builder-el-27  avia-builder-el-no-sibling  first flex_column_div '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lcspity9-9057e168f314a42220936a3d9d25652a\">\n#top .av-special-heading.av-lcspity9-9057e168f314a42220936a3d9d25652a{\npadding-bottom:30px;\nfont-size:50px;\n}\nbody .av-special-heading.av-lcspity9-9057e168f314a42220936a3d9d25652a .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-lcspity9-9057e168f314a42220936a3d9d25652a .av-special-heading-tag{\nfont-size:50px;\n}\n.av-special-heading.av-lcspity9-9057e168f314a42220936a3d9d25652a .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-lcspity9-9057e168f314a42220936a3d9d25652a .av-special-heading-tag{\nfont-size:30px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-lcspity9-9057e168f314a42220936a3d9d25652a .av-special-heading-tag{\nfont-size:30px;\n}\n}\n<\/style>\n<div  class='av-special-heading av-lcspity9-9057e168f314a42220936a3d9d25652a av-special-heading-h2 blockquote modern-quote  avia-builder-el-28  el_before_av_textblock  avia-builder-el-first  av-inherit-size'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >Validation parameters<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-lcqyox22-13875b4222ecc506f738dcf5d6dc6cd4'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock hhac-table'  itemprop=\"text\" ><table style=\"border-collapse: collapse; width: 100%; height: 95px;\">\n<thead>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 38px;\" rowspan=\"2\">Parameter<\/th>\n<th style=\"width: 20%; height: 38px; text-align: center;\" rowspan=\"2\">Identity<\/th>\n<th style=\"width: 20%; height: 19px; text-align: center;\" colspan=\"2\">Impurities<\/th>\n<th style=\"width: 20%; height: 38px; text-align: center;\" rowspan=\"2\">Content<\/th>\n<\/tr>\n<tr style=\"height: 19px;\">\n<th style=\"width: 20%; height: 19px; text-align: center;\">Quantitative<\/th>\n<th style=\"width: 20%; height: 19px; text-align: center;\">Limit test<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Accuracy<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Precision<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\"><\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\"><\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\"><\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Repeatability precision<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\"><\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Comparison precision(<sup>1<\/sup>)<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\"><\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Specificity\/Selectivity (<sup>2<\/sup>)<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Limit of detection &#8220;LOD&#8221;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\"><sup>3<\/sup><\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Limit of quantification &#8220;LOQ&#8221;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Linearity<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<\/tr>\n<tr style=\"height: 19px;\">\n<td style=\"width: 20%; height: 19px;\">Measuring range<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">&#8211;<\/td>\n<td style=\"width: 20%; height: 19px; text-align: center;\">x<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>(<sup>1<\/sup>) If a laboratory comparison is performed, the reproducibility or &#8220;Intermediate Precision&#8221; is not applicable.<\/p>\n<p>(<sup>2<\/sup>) A lack of specificity can be compensated by a second method<\/p>\n<p>(<sup>3<\/sup>) Necessary in certain cases<\/p>\n<\/div><\/section><\/p><\/div><\/div><\/div><\/div><!-- close content main div --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-nbkvpk-b597f569e58f58ba95c5f5b89536ad0b\">\n.avia-section.av-nbkvpk-b597f569e58f58ba95c5f5b89536ad0b{\nbackground-color:#ffffff;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_3'  class='avia-section av-nbkvpk-b597f569e58f58ba95c5f5b89536ad0b main_color avia-section-default avia-no-border-styling  avia-builder-el-30  el_after_av_section  avia-builder-el-last  avia-bg-style-scroll container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-3797'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-mh5uew-80f59f1d74c4ff1c03456e267b98cb14\">\n.flex_column.av-mh5uew-80f59f1d74c4ff1c03456e267b98cb14{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-mh5uew-80f59f1d74c4ff1c03456e267b98cb14 av_one_full  avia-builder-el-31  el_before_av_one_half  avia-builder-el-first  first flex_column_div av-zero-column-padding '     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l9q248-af75145c8aad587271e10577eb27c48e\">\n#top .av_textblock_section.av-l9q248-af75145c8aad587271e10577eb27c48e .avia_textblock{\ncolor:#b8b9bb;\n}\n<\/style>\n<section  class='av_textblock_section av-l9q248-af75145c8aad587271e10577eb27c48e'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock av_inherit_color'  itemprop=\"text\" ><h3>THE PROCEDURE FOR THE<\/h3>\n<\/div><\/section><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-in1a2g-2d3b02e5a04ebad4ef4fbace2142e6e9\">\n#top .hr.hr-invisible.av-in1a2g-2d3b02e5a04ebad4ef4fbace2142e6e9{\nmargin-top:-50px;\nheight:1px;\n}\n<\/style>\n<div  class='hr av-in1a2g-2d3b02e5a04ebad4ef4fbace2142e6e9 hr-invisible  avia-builder-el-33  el_after_av_textblock  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-hrwiug-1659124279a15b5606926827e3f2cff1\">\n#top .av-special-heading.av-hrwiug-1659124279a15b5606926827e3f2cff1{\npadding-bottom:30px;\nfont-size:50px;\n}\nbody .av-special-heading.av-hrwiug-1659124279a15b5606926827e3f2cff1 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-hrwiug-1659124279a15b5606926827e3f2cff1 .av-special-heading-tag{\nfont-size:50px;\n}\n.av-special-heading.av-hrwiug-1659124279a15b5606926827e3f2cff1 .av-subheading{\nfont-size:15px;\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n#top #wrap_all .av-special-heading.av-hrwiug-1659124279a15b5606926827e3f2cff1 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n#top #wrap_all .av-special-heading.av-hrwiug-1659124279a15b5606926827e3f2cff1 .av-special-heading-tag{\nfont-size:30px;\n}\n}\n<\/style>\n<div  class='av-special-heading av-hrwiug-1659124279a15b5606926827e3f2cff1 av-special-heading-h2 blockquote modern-quote  avia-builder-el-34  el_after_av_hr  el_before_av_textblock  av-inherit-size'><h2 class='av-special-heading-tag'  itemprop=\"headline\"  >Validation report<\/h2><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-fmyoc8-6e0da2700785303829ea13566dfb9dd3'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>The validation process is completed with the finalization of the validation report.<\/p>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-euj0hk-07891ae167925b25a6d31aff136c217a\">\n.flex_column.av-euj0hk-07891ae167925b25a6d31aff136c217a{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-euj0hk-07891ae167925b25a6d31aff136c217a av_one_half  avia-builder-el-36  el_after_av_one_full  el_before_av_one_half  first flex_column_div av-zero-column-padding column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-brd64o-fbd7eafa7d8c07ebea065623ad97249e\">\n#top .avia-icon-list-container.av-brd64o-fbd7eafa7d8c07ebea065623ad97249e .iconlist_icon{\ncolor:#0c8a7b;\nbackground-color:#ffffff;\n}\n#top #wrap_all .avia-icon-list-container.av-brd64o-fbd7eafa7d8c07ebea065623ad97249e .av_iconlist_title{\nfont-size:16px;\ncolor:#b8b9bb;\n}\n.avia-icon-list-container.av-brd64o-fbd7eafa7d8c07ebea065623ad97249e .iconlist_content{\nfont-size:16px;\ncolor:#000000;\n}\n<\/style>\n<div  class='avia-icon-list-container av-brd64o-fbd7eafa7d8c07ebea065623ad97249e  avia-builder-el-37  avia-builder-el-no-sibling '><ul class='avia-icon-list avia_animate_when_almost_visible avia-icon-list-left av-iconlist-big av-brd64o-fbd7eafa7d8c07ebea065623ad97249e avia-iconlist-animate'>\n<li><div class='iconlist_icon av-akwqzc-6bf88d08034f9d177a6dae5968e2b70b avia-font-entypo-fontello'><span class='iconlist-char' aria-hidden='true' data-av_icon='\ue875' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\"><\/header><div class='iconlist_content av_inherit_color'  itemprop=\"text\" ><p style=\"margin-top: -3px;\">The customer receives this report either in German or English.<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<li><div class='iconlist_icon av-v5888-e357bb10c83df2299f25d6772b211702 avia-font-entypo-fontello'><span class='iconlist-char' aria-hidden='true' data-av_icon='\ue875' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\"><\/header><div class='iconlist_content av_inherit_color'  itemprop=\"text\" ><p style=\"margin-top: -3px;\">In the case of more complex projects, our customer first receives a draft of the report, which is then jointly discussed. Upon request, we will also be happy to prepare a corresponding test method.<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<\/ul><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-88fze0-9e64d6f8adbd8771f0acb0fe299cab29\">\n.flex_column.av-88fze0-9e64d6f8adbd8771f0acb0fe299cab29{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-88fze0-9e64d6f8adbd8771f0acb0fe299cab29 av_one_half  avia-builder-el-38  el_after_av_one_half  avia-builder-el-last  flex_column_div av-zero-column-padding column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-6ljzy0-816f91c459d93e1d96e3aa5679b96ec1\">\n#top .avia-icon-list-container.av-6ljzy0-816f91c459d93e1d96e3aa5679b96ec1 .iconlist_icon{\ncolor:#0c8a7b;\nbackground-color:#ffffff;\n}\n#top #wrap_all .avia-icon-list-container.av-6ljzy0-816f91c459d93e1d96e3aa5679b96ec1 .av_iconlist_title{\nfont-size:16px;\ncolor:#b8b9bb;\n}\n.avia-icon-list-container.av-6ljzy0-816f91c459d93e1d96e3aa5679b96ec1 .iconlist_content{\nfont-size:16px;\ncolor:#000000;\n}\n<\/style>\n<div  class='avia-icon-list-container av-6ljzy0-816f91c459d93e1d96e3aa5679b96ec1  avia-builder-el-39  avia-builder-el-no-sibling '><ul class='avia-icon-list avia_animate_when_almost_visible avia-icon-list-left av-iconlist-big av-6ljzy0-816f91c459d93e1d96e3aa5679b96ec1 avia-iconlist-animate'>\n<li><div class='iconlist_icon av-3zo5k8-08d56a66b1df3e92a7bf517f85e44734 avia-font-entypo-fontello'><span class='iconlist-char' aria-hidden='true' data-av_icon='\ue875' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\"><\/header><div class='iconlist_content av_inherit_color'  itemprop=\"text\" ><p style=\"margin-top: -3px;\">Following their implementation validated methods are verified according to USP&lt;1226&gt;. This ensures that they are used professionally and can be quickly adopted in the routine operation.<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<li><div class='iconlist_icon av-2k35pk-40d19a74addd345045703e3780ee721d avia-font-entypo-fontello'><span class='iconlist-char' aria-hidden='true' data-av_icon='\ue875' data-av_iconfont='entypo-fontello'><\/span><\/div><article class=\"article-icon-entry \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconlist_content_wrap\"><header class=\"entry-content-header\"><\/header><div class='iconlist_content av_inherit_color'  itemprop=\"text\" ><p style=\"margin-top: -3px;\">Successful method development and validation ensures fast and smooth method transfers and thus the fastest possible use of the validated method.<\/p>\n<\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class=\"iconlist-timeline\"><\/div><\/li>\n<\/ul><\/div><\/div><\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_3'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-3797'><div class='entry-content-wrapper clearfix'>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":13,"featured_media":0,"parent":3781,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3797","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages\/3797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/comments?post=3797"}],"version-history":[{"count":0,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages\/3797\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/pages\/3781"}],"wp:attachment":[{"href":"https:\/\/hhac.de\/en\/wp-json\/wp\/v2\/media?parent=3797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}